Evidence map›Paper›PMID 42690239›Full record

ArticleBiomedical microdevices2026

Fabrication and characterization of spin-coated multilayer surface-eroding implants for automated multi-pulse drug delivery.

Parker R Brewster, Katherine Nevils, Lilly Ates, Acelynn Sellers, Heath Stevens, Omayma Alazzam, Glenn M Walker, Thomas A Werfel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical microdevices, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Parker R BrewsterDepartment of Biomedical Engineering, University of Mississippi, University, MS, 38677, USA.
Katherine NevilsDepartment of Biomedical Engineering, University of Mississippi, University, MS, 38677, USA.
Lilly AtesDepartment of Mechanical Engineering, University of Mississippi, University, MS, 38677, USA.
Acelynn SellersDepartment of Biomedical Engineering, University of Mississippi, University, MS, 38677, USA.
Heath StevensDepartment of Biomedical Engineering, University of Mississippi, University, MS, 38677, USA.
Omayma AlazzamDepartment of Biomedical Engineering, University of Mississippi, University, MS, 38677, USA.
Glenn M WalkerDepartment of Biomedical Engineering, University of Mississippi, University, MS, 38677, USA.
Thomas A WerfelDepartment of Biomedical Engineering, University of Mississippi, University, MS, 38677, USA. tawerfel@olemiss.edu.

Funding

Microdosing Implant to Mitigate Depression Associated with Opioid Use DisorderR41EB036916 · NIBIB · INTERVAL THERAPEUTICS LLC · PI HEATH, KATIE, WALKER, GLENN MADISON · 2024 to 2024
$307k
Mississippi Institutes of Higher Learning 2024-15NIBIB NIH HHS R41 EB036916NIH HHS 1R41EB036916-01A1
6 · The paper itself

Abstract

Medication nonadherence contributes to disease progression, avoidable hospitalization, and an estimated $100-300 billion in annual excess healthcare costs in the United States. Implants that encode a dosing schedule during fabrication offer an alternative to patient-dependent administration. Here we apply spin coating to build multilayer surface-eroding implants from cellulose acetate phthalate (CAP) and Pluronic F-127, stacking fluorescein-loaded poly(vinyl alcohol) active layers between degradable CAP-Pluronic composite (CAPP) barrier layers whose thickness sets the interval between release events. Spin-curve calibration gave an inverse power-law dependence of thickness on rotational speed (R² = 0.979) from 436 ± 9 to 92 ± 4 μm. Against solvent-cast films produced from a necessarily different formulation at a matched 400 μm nominal target, spin coating reduced batch-to-batch standard deviation from approximately 34 to 2 μm and within-film standard deviation from 43-47 to 5-12 μm (n = 3 independently fabricated films per method); at a 100 μm target it reduced the maximum surface excursion below the mean plane, measured by atomic force microscopy, from 146.1 to 4.5 nm; confocal Raman mapping showed the standard deviation of the CAP/F-127 peak-height ratio falling from 2.91 to 0.77. Two device configurations, designated Q16 and Q72 after the approximately 16 and 72 h inter-pulse intervals they produced, each gave three discrete release events with near-baseline inter-pulse signal (n = 6 devices per condition).

Indexed as

Drug Delivery SystemsDrug ImplantsAutomationCelluloseFluoresceinPoloxamerPolyvinyl AlcoholSurface PropertiesCellulosecellulose acetate phthalateDrug ImplantsFluoresceinPoloxamerPolyvinyl AlcoholCellulose acetate phthalateMultilayer implantPulsatile drug deliverySpin coatingSurface-eroding polymers

Identifiers

PMID42690239
PMCPMC13541886

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.