Evidence map›Paper›PMID 42689334›Full record

ArticleCirculation research2026

3-Dimensional Human iPSC-Derived Cardiac Organoids for Antifibrotic Drug Screening.

Hao Zhang, Rihua Huang, Phung N Thai, Lu Ren, Rabindra V Shivnaraine, Wenjuan Zhu, Yuanyuan Dai, Wenqiang Liu, Mengjie Xie, Xiu Liu and 8 more

Abstract readLetter
In one paragraph

Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Hao Zhang *Stanford Cardiovascular Institute (H.Z., R.H., L.R., W.Z., Y.D., W.L., M.X., X.L., R.T., X.Y., X.C., X.W., J.C.W.), Stanford University School of Medicine, Stanford, CA.ORCID 0000-0002-2646-0959
Rihua Huang *Stanford Cardiovascular Institute (H.Z., R.H., L.R., W.Z., Y.D., W.L., M.X., X.L., R.T., X.Y., X.C., X.W., J.C.W.), Stanford University School of Medicine, Stanford, CA.ORCID 0000-0002-5399-0074
Phung N ThaiDepartment of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA (H.Z., P.N.T.).ORCID 0000-0001-7344-150X
Lu RenStanford Cardiovascular Institute (H.Z., R.H., L.R., W.Z., Y.D., W.L., M.X., X.L., R.T., X.Y., X.C., X.W., J.C.W.), Stanford University School of Medicine, Stanford, CA.ORCID 0000-0002-9731-8562
Rabindra V ShivnaraineAerys Biosciences, Palo Alto, CA (R.V.S.).ORCID 0000-0002-1478-5422
Wenjuan ZhuStanford Cardiovascular Institute (H.Z., R.H., L.R., W.Z., Y.D., W.L., M.X., X.L., R.T., X.Y., X.C., X.W., J.C.W.), Stanford University School of Medicine, Stanford, CA.ORCID 0000-0003-2724-4825
Yuanyuan DaiStanford Cardiovascular Institute (H.Z., R.H., L.R., W.Z., Y.D., W.L., M.X., X.L., R.T., X.Y., X.C., X.W., J.C.W.), Stanford University School of Medicine, Stanford, CA.
Wenqiang LiuStanford Cardiovascular Institute (H.Z., R.H., L.R., W.Z., Y.D., W.L., M.X., X.L., R.T., X.Y., X.C., X.W., J.C.W.), Stanford University School of Medicine, Stanford, CA.ORCID 0000-0002-2323-7962
Mengjie XieStanford Cardiovascular Institute (H.Z., R.H., L.R., W.Z., Y.D., W.L., M.X., X.L., R.T., X.Y., X.C., X.W., J.C.W.), Stanford University School of Medicine, Stanford, CA.ORCID 0000-0003-4415-8267
Xiu LiuStanford Cardiovascular Institute (H.Z., R.H., L.R., W.Z., Y.D., W.L., M.X., X.L., R.T., X.Y., X.C., X.W., J.C.W.), Stanford University School of Medicine, Stanford, CA.ORCID 0000-0001-7818-8312
Renke TanStanford Cardiovascular Institute (H.Z., R.H., L.R., W.Z., Y.D., W.L., M.X., X.L., R.T., X.Y., X.C., X.W., J.C.W.), Stanford University School of Medicine, Stanford, CA.ORCID 0000-0002-7669-3996
Xiaochun YangStanford Cardiovascular Institute (H.Z., R.H., L.R., W.Z., Y.D., W.L., M.X., X.L., R.T., X.Y., X.C., X.W., J.C.W.), Stanford University School of Medicine, Stanford, CA.ORCID 0000-0002-9937-965X
Xu CaoStanford Cardiovascular Institute (H.Z., R.H., L.R., W.Z., Y.D., W.L., M.X., X.L., R.T., X.Y., X.C., X.W., J.C.W.), Stanford University School of Medicine, Stanford, CA.ORCID 0000-0002-8368-6727
Xuekun WuStanford Cardiovascular Institute (H.Z., R.H., L.R., W.Z., Y.D., W.L., M.X., X.L., R.T., X.Y., X.C., X.W., J.C.W.), Stanford University School of Medicine, Stanford, CA.
Matthew A WuGreenstone Biosciences, Palo Alto, CA (R.V.S., M.A.W.).
Christopher CaridiSarafan ChEM-H Nucleus, High-Throughput Screening and Innovative Medicines Accelerator (IMA; C.C., D.S.-C.), Stanford University School of Medicine, Stanford, CA.
David Solow-CorderoSarafan ChEM-H Nucleus, High-Throughput Screening and Innovative Medicines Accelerator (IMA; C.C., D.S.-C.), Stanford University School of Medicine, Stanford, CA.ORCID 0000-0002-9886-5058
Joseph C WuStanford Cardiovascular Institute (H.Z., R.H., L.R., W.Z., Y.D., W.L., M.X., X.L., R.T., X.Y., X.C., X.W., J.C.W.), Stanford University School of Medicine, Stanford, CA.ORCID 0000-0002-6068-8041

Funding

Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCsR01HL130020 · NHLBI · STANFORD UNIVERSITY · PI Ronglih Liao, MARK MERCOLA · 2016 to 2026
$7.3M
Elucidating Sex Differences in Radiation-induced Cardiotoxicity with Cell Village iPSCsU01AI183953 · NIAID · STANFORD UNIVERSITY · PI Adam J Chicco, Joseph C. Wu · 2024 to 2026
$1.6M
AI-driven Drug Discovery Targeting Cardiac Fibrosis in Aging HeartUG3AG097135 · NIA · STANFORD UNIVERSITY · PI SAYED, NAZISH, WU, JOSEPH C. · 2025 to 2025
$900k
Targeting Immune-Fibroblast Crosstalk in Genetic Dilated CardiomyopathyR01HL185054 · NHLBI · STANFORD UNIVERSITY · PI Wing H. WONG, Joseph C. Wu · 2026 to 2026
$769k
Mechanisms of Tyrosine Kinase Inhibitor-induced Sinoatrial Node DysfunctionK99HL179374 · NHLBI · STANFORD UNIVERSITY · PI Lu Ren · 2026 to 2026
$153k
NHLBI NIH HHS K99 HL179374NHLBI NIH HHS R01 HL130020NHLBI NIH HHS R01 HL185054NIAID NIH HHS U01 AI183953NIA NIH HHS UG3 AG097135
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

extracellular matrixfibrosisinduced pluripotent stem cellsmyocytes, cardiacorganoids

Identifiers

PMID42689334
PMCPMC13649265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.