Evidence map›Paper›PMID 42689298›Full record

ArticleJournal of advanced pharmaceutical technology & research

Combined inulin, glucomannan, and medium-chain triglyceride modulate metabolic and inflammatory responses in chemotherapy-treated colorectal cancer cells.

Bernadette Dian Novita, Yudy Tjahjono, Martha Ervina, Suryo Kuncorojakti, Andi Yasmin Wijaya, I Gede Putu Adhi Wedharga, Hendy Wijaya, Sianty Dewi, Herjuniato, Felix Christ Antono and 2 more

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In one paragraph

Article in Journal of advanced pharmaceutical technology & research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bernadette Dian NovitaDepartment of Pharmacology and Therapy, Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, Indonesia.
Yudy TjahjonoDepartment of Faculty of Pharmacy, Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, Indonesia.
Martha ErvinaDepartment of Faculty of Pharmacy, Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, Indonesia.
Suryo KuncorojaktiResearch Center for Vaccine Technology and Development, Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia.
Andi Yasmin WijayaMagister Program Faculty of Medicine Airlangga University, Surabaya, Indonesia.
I Gede Putu Adhi WedhargaDepartment of Undergraduate Program, Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, Indonesia.
Hendy WijayaDepartment of Faculty of Pharmacy, Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, Indonesia.
Sianty DewiDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, Indonesia.
HerjuniatoDepartment of Internal Medicine, Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, Indonesia.
Felix Christ AntonoDepartment of Undergraduate Program, Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, Indonesia.
Cornelia ValerieDepartment of Pharmacology and Therapy, Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, Indonesia.
Hevi WihadmadyatamiMedical Veterinary Faculty, University of Gadjah Mada, Yogyakarta, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) remains a global health challenge. The efficacy of 5-fluorouracil (5-FU) is frequently limited by chemoresistance, inflammation, and compensatory pro-angiogenic signaling. Prebiotic fibers and metabolically active lipids have been shown to modulate immune-metabolic pathways that may influence tumor behavior and chemotherapy response. The aim of the study was to evaluate the immunomodulatory and chemo-adjunct effects of inulin, glucomannan, and a combined inulin-glucomannan-medium-chain triglyceride (MCT) formulation on CRC cells exposed to 5-FU. An

Indexed as

Adjunctive therapychemotherapycolorectal cancer cellsglucomannaninulinmedium-chain triglyceride

Identifiers

PMID42689298
PMCPMC13537780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.