ArticleJournal of biomedical optics2026
Single-fiber reflectance spectroscopy system using unmodified clinical laser fibers for tissue optical property recovery for photodynamic therapy treatment planning.
Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 authors.
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Abstract
Significance: Estimation of tissue optical properties in workflow- and resource-constrained clinical settings is required to support photodynamic therapy (PDT) treatment planning, yet large-scale clinical translation remains limited by spectroscopy probe cost, complexity, and the need for probe-specific inverse models. Single-fiber reflectance (SFR) spectroscopy offers a simple and low-cost option, but previous implementations relied on customized angle-polished fibers. Aim: The objective was to develop a proof-of-concept SFR spectroscopy system employing an unmodified, United States Food and Drug Administration (FDA)-approved clinical optical fiber for quantitative optical property extraction. Approach: A semi-empirical photon pathlength model was used to recover the absorption spectra Results: Optical property retrieval from measurements acquired using three nominally identical fibers demonstrated clinically sufficient accuracy across fibers without requiring model adaptation. Across all fibers, MB concentration Conclusions: We demonstrate the potential of SFR spectroscopy using a standard clinical optical fiber as a scalable and clinically useful tool for tissue optical property estimation to support PDT treatment planning.
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