Evidence map›Paper›PMID 42689244›Full record

ArticleACG case reports journal2026

Recurrent Sickle Cell Hepatopathy After Liver Transplantation Despite Guideline-Directed Red Blood Cell Exchange.

Muhammad Nouman Aslam, Maddison Weber, Ahmed Al-Hindawi, Sarah Park, Gautam Maddineni, Anjana Pillai

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in ACG case reports journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Muhammad Nouman AslamInternal Medicine Department, Creighton University School of Medicine, Omaha, NE.ORCID https://orcid.org/0009-0005-1013-2044
Maddison WeberInternal Medicine Department, Creighton University School of Medicine, Omaha, NE.
Ahmed Al-HindawiInternal Medicine Department, Creighton University School of Medicine, Omaha, NE.
Sarah ParkDivision of Gastroenterology, Hepatology and Nutrition, University of Chicago Medical Center, University of Chicago, Chicago, IL.
Gautam MaddineniInternal Medicine Department, Creighton University School of Medicine, Omaha, NE.
Anjana PillaiDivision of Gastroenterology, Hepatology and Nutrition, University of Chicago Medical Center, University of Chicago, Chicago, IL.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sickle cell hepatopathy is an uncommon but severe cause of liver dysfunction after transplantation. We present a case of a 37-year-old man who developed recurrent sickle cell hepatopathy 12 months postliver transplant despite maintaining hemoglobin S (HbS) levels below 30% per American Society of Hematology recommendations. Liver biopsy demonstrated sinusoidal sickling without rejection. Liver tests improved after intensifying red cell exchange to achieve HbS below 20%. This case illustrates that standard posttransplant HbS targets may be insufficient in high-risk patients and highlights the need for individualized HbS goals.

Indexed as

hemoglobin Sliver transplantationposttransplant complicationsred blood cell exchangesickle cell diseasesickle cell hepatopathy

Identifiers

PMID42689244
PMCPMC13537713

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.