Evidence map›Paper›PMID 42689192›Full record

ArticleHuman mutation2026

Human Variation-Informed Prioritization of MPHOSPH6 in Lung Adenocarcinoma: A Source-Aware Multiomics Evidence Framework.

Chongwen Fang, Min Wu, Jing Lv, Yanping Zhang, Qinyun Zheng, Xiang Shen, Shangke Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chongwen FangDepartment of Gastroenterology, Anqing Municipal Hospital, Anqing, China, aqslyy.com.cn.
Min WuDepartment of Thoracic Surgery, West China Hospital of Sichuan University-Ziyang Hospital, Ziyang City Central Hospital, Ziyang, China.
Jing LvDepartment of Orthopedics, West China Hospital of Sichuan University-Ziyang Hospital, Ziyang City Central Hospital, Ziyang, China.ORCID https://orcid.org/0000-0001-5842-1148
Yanping ZhangDepartment of Gastroenterology, Anqing Municipal Hospital, Anqing, China, aqslyy.com.cn.
Qinyun ZhengDepartment of Health Management Center, Chongqing General Hospital, Chongqing University, Chongqing, China, cqu.edu.cn.
Xiang ShenDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China, ahswmu.cn.
Shangke HuangDepartment of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China, ahswmu.cn.ORCID https://orcid.org/0000-0002-9356-7588

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Moving from an association signal to a clinically credible biomarker requires several links that are often conflated: verified variant identity, aligned allelic effects, reproducible gene-level association, relevant cellular expression, and a plausible functional consequence. We developed a source-aware multiomics framework to assess MPHOSPH6 in lung adenocarcinoma (LUAD) while keeping those evidence classes separate. Six prespecified rsIDs were recovered from the harmonized TRICL LUAD dataset, of which five reached

Indexed as

Adenocarcinoma of LungGenetic VariationLung NeoplasmsAllelesBiomarkers, TumorGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMultiomicsPolymorphism, Single NucleotideBiomarkers, TumorGWAShuman genetic variationlung adenocarcinomamissense variationMPHOSPH6multiomics biomarkerpredicted gene expressionsingle-cell pseudobulk

Identifiers

PMID42689192
PMCPMC13537304

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.