Evidence map›Paper›PMID 42689138›Full record

ArticleMedComm2026

Early Local Treatment Delays Multiple Metastases in Non-Small Cell Lung Cancer With Solitary Distant Metastasis: A Multicenter Retrospective Cohort Study.

Kang Miao, Siyu Lei, Xiaobin Zheng, Shanshan Yang, Yujing Li, Sihui Chen, Qian Miao, Longfeng Zhang, Zihua Zou, Haipeng Xu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kang Miao *Department of Thoracic Oncology NHC Key Laboratory of Cancer and Metabolism Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital Fuzhou China.
Siyu Lei *Department of Medical Oncology Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing Chest Hospital, Capital Medical University Beijing China.
Xiaobin ZhengDepartment of Medical Oncology Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing Chest Hospital, Capital Medical University Beijing China.
Shanshan YangDepartment of Thoracic Oncology NHC Key Laboratory of Cancer and Metabolism Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital Fuzhou China.
Yujing LiDepartment of Thoracic Oncology NHC Key Laboratory of Cancer and Metabolism Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital Fuzhou China.
Sihui ChenDepartment of Thoracic Oncology NHC Key Laboratory of Cancer and Metabolism Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital Fuzhou China.
Qian MiaoDepartment of Thoracic Oncology NHC Key Laboratory of Cancer and Metabolism Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital Fuzhou China.
Longfeng ZhangDepartment of Thoracic Oncology NHC Key Laboratory of Cancer and Metabolism Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital Fuzhou China.
Zihua ZouDepartment of Thoracic Oncology NHC Key Laboratory of Cancer and Metabolism Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital Fuzhou China.
Haipeng XuDepartment of Thoracic Oncology NHC Key Laboratory of Cancer and Metabolism Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital Fuzhou China.
Gen LinDepartment of Medical Oncology Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing Chest Hospital, Capital Medical University Beijing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Solitary distant metastasis (SDM) is a distinct oligometastatic subtype associated with a relatively favorable prognosis. This multicenter retrospective study including 139 non-small cell lung cancer (NSCLC) patients with SDM (2019-2024) was conducted to investigate prognostic factors for multiple metastases and identify the critical time window for local treatment. Statistical analyses included Cox regression, Kaplan-Meier survival analysis, and restricted mean survival time (RMST). Results showed that driver gene status, tumor staging, systemic therapy, and local treatment were significantly associated with progression-free survival (PFS). Notably, only early local treatment significantly delayed the onset of multiple metastases (hazard ratio [HR] = 0.55, 95% confidence interval [CI]: 0.30-0.99,

Indexed as

local treatmentnon‐small cell lung cancerrestricted mean survival timesolitary distant metastasistime to multiple metastases

Identifiers

PMID42689138
PMCPMC13537008

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.