Systematic evaluation of genetic polymorphisms in carcinogen metabolizing enzymes associated with oral potentially malignant disorders progression to oral cancer risk.

Ziyuan Xu, Yuhan Zhu, Linjun Shi, Wei Liu

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Article in Journal of dental sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Ziyuan XuDepartment of Stomatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Yuhan ZhuDepartment of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Linjun ShiCollege of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.

Wei LiuDepartment of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

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6 · The paper itself

Abstract

Background/purpose: Increasing studies investigate the association of polymorphisms in carcinogen-metabolizing enzymes with oral potentially malignant disorder (OPMD) progression to oral squamous cell carcinoma (OSCC) risk. However, these results remain inconsistent and conflicting. This pooled analysis aimed to systematically evaluate the 5 enzymes (CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1) polymorphisms in OPMD versus OSCC. Materials and methods: A systematic literature search was conducted to identify all eligible case-control studies on the association between SNPs in the 5 enzymes in OPMD versus OSCC. Pooled odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated to access association strength. Results: No significant association of CYP1A1 MspI polymorphism (OR, 1.38; 95%CI, 0.80-2.38) in OPMD with OSCC risk was observed based on 5 eligible studies involving 624 cases of OPMD and 1529 OSCC. As for Conclusion: This is the first pooled analysis on polymorphisms in carcinogen-metabolizing enzymes in OPMD versus OSCC. The results suggested that the GSTM1 null genotype was a significant genetic risk factor for OPMD progression to OSCC, highlighting its potential for improving risk stratification and early detection, particularly for oral leukoplakia.

Indexed as

Carcinogen metabolismMeta-analysisOral cancerOral leukoplakiaOral potentially malignant disordersSingle-nucleotide polymorphisms

Identifiers

PMID42689117

DOI10.1016/j.jds.2025.12.021

PMCPMC13536456

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