ArticleJournal of dental sciences2026
Optogenetic control of odontoblastic differentiation in dental pulp stem cells (DPSC).
Article in Journal of dental sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Modern Drug Delivery Platforms Based on Photocrosslinkable Hydrogels (PCHs) in Dentistry: From Material Characteristics to Clinical Applications-A Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
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Authors and funding
1 author.
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Abstract
Background/purpose: Dental Pulp Stem Cells (DPSC) are sensitive to ionic and electrical cues governing mineralization. We developed a photo-responsive Materials and methods: A commercially available, non-clinical-grade DPSC line was transfected with a modular light-gated cation channel (Opto-Ca Results: Illuminated cultures displayed a threefold increase in ALP and enhanced calcium deposition relative to dark controls. Quantitative polymerase chain reaction (qPCR) revealed significant up-regulation of DSPP (≈4.5 × ) and DMP1 (≈3.8 × ). Confocal imaging confirmed transient intracellular Ca Conclusion: Optically gated ion channels provide a tunable strategy for light-directed odontoblastic differentiation. The system demonstrates a route toward photo-regulated biomineralization and light-responsive dental scaffolds that unify biophotonics and regenerative dentistry.
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