ArticleJournal of dental sciences2026
2-hydroxy ethylmethacrylate activates the extrinsic and intrinsic apoptotic processes through mitogen-activated protein kinase signaling pathways in cementoblasts - An
Article in Journal of dental sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/purpose: 2-Hydroxy ethylmethacrylate (HEMA) is a hydrophilic monomer that may be released from composite resin after polymerization. Little is known about the adverse effects of HEMA on cementoblasts. Therefore, this study investigated the possible mechanisms underlying the cytotoxicity engendered by HEMA on murine cementoblast cell line (OCCM.30). Materials and methods: OCCM.30 cells were cultured with HEMA (0, 2, 4, and 8 mM) for 24 h. Cell viability was determined by microculture tetrazolium assay. Flow cytometry with annexin V-FITC/propidium iodide apoptosis staining was conducted to evaluate the cell cycle distribution and the type of cell death. Western blot was employed to investigate the caspase-mediated apoptotic cell death and mitogen-activated protein kinase (MAPK) pathways. Results: The concentrations of HEMA≧4 mM significantly inhibited cell viability in a concentration-dependent manner ( Conclusion: The results demonstrated that HEMA decreased cell viability and induced caspase-mediated apoptosis in cementoblast by activating both extrinsic and intrinsic apoptotic pathways through ERK, JNK, and p38 signaling. These results may provide the preliminary information for the development of less cytotoxic composite resin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.