ArticleJournal of dental sciences2026
Mesenchymal stem cells derived from gingiva normoxic or hypoxic-preconditioning allogenous transplantation affect orthodontic tooth movement in vivo.
Article in Journal of dental sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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16 authors.
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Abstract
Background/purpose: Gingival mesenchymal stem cells (GMSC) show promising qualities in immunoregulation, immunomodulation in regeneration of periodontal tissue during orthodontic tooth movement (OTM). This study aimed to elucidate allogenous GMSC normoxia and hypoxic preconditioning transplantation in the OTM model using New Zealand rabbits ( Materials and methods: Four groups were established from forty-eight, healthy, young male rabbits divided into the following respective groups: p1: normoxic GMSC transplantation with OTM, p2: hypoxic GMSC transplantation with OTM, k2: OTM only, and K1: phosphate buffered saline (PBS) only. In order to advance the mandibular first molar mesially, a fixed orthodontic appliance was applied. The rabbit was transplanted with 10 Results: There was a considerable increase in OTM rate, osteocalcin and RUNX2 expression in P2 on day 28 with significantly different between groups. In contrast to other groups, the P2 group's expression of NFKβ, TNF-α, and NFATc1 was considerably lower on day 28 in the tension side of the alveolar bone ( Conclusion: GMSC hypoxia-preconditioning transplantation increases the OTM rate through the RUNX2-osteocalcin-OTM rate stimulation pathway in rabbits (
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