Evidence map›Paper›PMID 42689040›Full record

ArticleJournal of dental sciences2026

Endothelin-1 drives COX-2 and prostaglandin E

Fang-Yu Fan, Thi Thuy Tien Vo, Hsuan Kuo, Chien-Fu Tseng, Wei-Ning Lin, Chia-Yu Wu, Yang-Che Wu, Chuen-Mao Yang, Li-Der Hsiao, I-Ta Lee

Abstract read
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In one paragraph

Article in Journal of dental sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fang-Yu Fan *School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Thi Thuy Tien VoFaculty of Dentistry, Nguyen Tat Thanh University, Ho Chi Minh City, Viet Nam.
Hsuan Kuo *Division of Oral and Maxillofacial Surgery, Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan.
Chien-Fu Tseng *Graduate Institute of Clinical Dentistry, School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan.
Wei-Ning LinGraduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City, Taiwan.
Chia-Yu WuSchool of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Yang-Che WuSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Chuen-Mao YangGraduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City, Taiwan.
Li-Der HsiaoGraduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City, Taiwan.
I-Ta LeeSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/purpose: Endothelin-1 (ET-1) has been implicated in inflammatory tissue responses, but its role in osteoblast-mediated inflammation during periodontal inflammation remains unclear. This study investigated whether ET-1 induces cyclooxygenase-2 (COX-2) expression and prostaglandin E Materials and methods: Murine osteoblast-like MC3T3-E1 cells were stimulated with ET-1. COX-2 protein and mRNA expression, promoter activity, and PGE Results: ET-1 increased COX-2 protein and mRNA expression, COX-2 promoter activity, and PGE Conclusion: ET-1 drives COX-2 expression and PGE

Indexed as

Activator protein-1Cyclooxygenase-2Endothelin-1OsteoblastsPeriodontal inflammationProstaglandin E2

Identifiers

PMID42689040
PMCPMC13536400

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.