Evidence map›Paper›PMID 42689026›Full record

ArticleJournal of dental sciences2026

Efficacy of concentrated growth factors preventing medication-related osteonecrosis of the jaw following tooth extraction in patients on intravenous bisphosphonates: A randomized controlled trial.

Peng Ye, Shu Li, Ying-Ying Fan, Bing-Xue Han, Chen-Wei Pei, Si-Si Zhang, Ye-Jun Cai, Xin Peng, Shan-Shan Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peng YeDepartment of Stomatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Shu LiDepartment of Stomatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Ying-Ying FanDepartment of Stomatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Bing-Xue HanDepartment of Stomatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Chen-Wei PeiDepartment of Stomatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Si-Si ZhangDepartment of Stomatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Ye-Jun CaiDepartment of Stomatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Xin PengDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.
Shan-Shan ZhuDepartment of Stomatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/purpose: Medication-related osteonecrosis of the jaw (MRONJ) constitutes a severe postoperative complication following tooth extraction in patients with intravenous bisphosphonates (BPs) exposure. This study aimed to evaluate concentrated growth factors (CGF) in preventing MRONJ and enhancing tissue healing after tooth extraction in intravenous BPs treated patients. Materials and methods: This randomized controlled trial enrolled 119 patients (150 extraction sites). Extraction sites were randomly allocated to minimally invasive extraction alone (control, N = 75) or with CGF (test, N = 75). MRONJ incidence was assessed at least 8 weeks postoperatively. Gingival buccolingual width and fissure area were measured immediately after extraction and at 1, 2, and 4 weeks postoperatively. Results: In the total cohort and the intravenous BPs combined with denosumab cohort, the incidence of MRONJ in the test group was significantly lower than that in the control group ( Conclusion: Minimally invasive tooth extraction with CGF may effectively reduce the risk of MRONJ and promote tissue healing in patients treated with intravenous BPs, particularly those receiving concomitant denosumab therapy.

Indexed as

Concentrated growth factorsMinimally invasive tooth extractionMRONJPrevention

Identifiers

PMID42689026
PMCPMC13536331

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.