Osteoclast-derived exosomes promote medication-related osteonecrosis of the jaw by delivering glycoRNA to disrupt the blood-lymphatic vascular network.

Jiankang Zhang, Junming Tao, Chengzhi Zhao, Jian Pan

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Article in Journal of dental sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Jiankang ZhangState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Junming TaoState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Chengzhi ZhaoState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Jian PanState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Funding

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6 · The paper itself

Abstract

Background/purpose: Medication-related osteonecrosis of the jaw (MRONJ) is a metabolic disorder of the jaw characterized by bone necrosis. Its pathogenesis remains unclear, and elucidating the underlying mechanisms and pathological changes is essential for addressing the clinical challenge of refractory jaw necrosis in MRONJ. Glycosylated RNA (glycoRNA), a recently identified class of small RNAs modified by glycosylation, plays important roles in intercellular communication, signal transduction, and autoimmunity; however, its role in the onset and progression of MRONJ has not yet been investigated. Materials and methods: Exosomes derived from zoledronate-induced osteoclasts (OC Results: GlycoRNA was shown to undergo intercellular transfer via exosomes. In vitro, OC Conclusion: These findings reveal a previously unrecognized mechanism by which zoledronate contributes to MRONJ: exosomes-mediated intercellular transfer of glycoRNA disrupts the blood-lymphatic vascular network and promotes jaw necrosis.

Indexed as

Blood—lymphatic vascular networkExosomesGlycoRNAMedication-related osteonecrosis of the jaw(MRONJ)

Identifiers

PMID42689024

DOI10.1016/j.jds.2025.07.3549

PMCPMC13536305

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