ArticleJournal of dental sciences2026
Clostridioides difficile infection risk and contemporary antibiotic use: Evidence from a large real-world dataset highlighting the need for a comprehensive antibiotic stewardship in dentistry.
Article in Journal of dental sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background/purpose: In dental care, antibiotics are frequently used for infection control. While certain antibiotics are historically linked to the increased risk of Materials and methods: We performed a retrospective cohort analysis using the TriNetX healthcare database to examine prior antibiotic exposure in patients diagnosed with CDI. The study focused on adults with confirmed CDI cases. To isolate a distinct patient group, individuals who had received standard CDI treatments vancomycin, metronidazole, or fidaxomicin either before or after diagnosis were excluded. This approach aimed to assess antibiotic exposure without the influence of common CDI therapies. Results: Out of 201,911 CDI patients analyzed, 33.9 % (68,535) had been exposed to antibiotics. Focusing on antibiotic use within the two weeks leading up to diagnosis. We identified distinct antibiotic classes, with the most used being extended-spectrum penicillin (18.6 %), third-generation cephalosporins (15.8 %), and amino penicillins (15.3 %). Conclusion: This study sheds light on real-world antibiotic prescribing patterns among a broad clinical population. Notably, historically high-risk antibiotics like clindamycin and fluoroquinolones were not the most frequently used prior to CDI diagnosis. These insights underscore the importance of comprehensive antibiotic stewardship across all classes prescribed in dental care.
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