ArticleJournal of advanced pharmaceutical technology & research
Combined inulin and glucomannan modulate colonic cytokine balance and mucosal barrier function in a western diet-induced colonic inflammation mouse model.
Article in Journal of advanced pharmaceutical technology & research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
15 authors.
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Abstract
A rising worldwide health concern, inflammatory bowel disease is linked to western-style diets that damage intestinal barrier integrity, change gut microbiota, and increase colonic inflammation. In contrast, inulin and glucomannan enhance short-chain fatty acid production and preserve mucosal structure, suggesting a protective role against diet-induced colonic inflammation. This study aimed to investigate whether combined inulin and glucomannan supplementation prevents western diet-induced colonic inflammation by modulating intestinal barrier function and colonic inflammatory cytokine profiles. Over 8 weeks, elicited by a high-fat, high-sucrose (HFHS) diet, colonic inflammation in mice as a model was utilized in a preventative experimental investigation. Mice received an HFHS diet with supplementation of inulin, glucomannan, or their combination. Colonic histopathology was evaluated, and interleukin 6 (IL-6) and IL-10 levels were assessed using immunohistochemistry. Statistical analyses included one-way analysis of variance with appropriate
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