ArticleJournal of dentistry (Shiraz, Iran)2026
Overexpression of MIEN1 in Oral Squamous Cell Carcinoma: Correlation with Tumor Invasion and Lymph Node Metastasis.
Article in Journal of dentistry (Shiraz, Iran), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Oral squamous cell carcinoma (OSCC) is a malignant tumor with a high potential for local invasion and distant metastasis. Migration and invasion enhancer 1 (MIEN1) is a recently identified protein that contributes to the pathogenesis of various cancers by promoting cell migration and invasion. Purpose: This study aimed to assess the expression of MIEN1 in OSCC and to compare it with its expression in dysplastic and hyperkeratotic oral epithelium. Materials and Method: In this retrospective study, MIEN1 expression was evaluated in 79 formalin-fixed, paraffin-embedded tissue samples, including 43 cases of OSCC, 23 of oral epithelial dysplasia, and 13 of hyperkeratotic oral epithelium, using immunohistochemical staining. The association between MIEN1 expression and clinicopathological parameters including patients age, sex, lesion location, tumor size, lymph node metastasis, and tumor-node-metastasis (TNM) stages was analyzed using the chi-square test, Fisher's exact test, and Mann-Whitney test at a significance level of Results: MIEN1 overexpression was significantly higher in OSCC compared to both moderate and mild dysplastic epithelium ( Conclusion: Our findings indicate that MIEN1 expression is correlated with the progression of OSCC. It likely plays a crucial role in the migration and invasion of cancer cells, as well as in the metastatic spread of the disease.
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