ArticleJournal of dentistry (Shiraz, Iran)2026
Efficacy of Leukocyte Platelet Rich Fibrin (L-PRF) Versus L-PRF with βeta Tri-calcium Phosphate (β-TCP) Bone Graft in Mandibular Impacted Third Molar Surgery: A Split-Mouth Double Blinded Randomized Control Study.
Article in Journal of dentistry (Shiraz, Iran), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Mandibular third molar removal surgically exhibits severe pain, edema, limitation in mouth opening, impaired wound healing, and delayed bone formation postoperatively. Purpose: To compare the effectiveness of leukocyte platelet-rich fibrin (L-PRF) and L-PRF with β-Tricalcium phosphate (β-TCP) bone graft on postoperative outcomes after mandibular impacted third molar surgery. Materials and Method: This split-mouth double-blinded randomized controlled study was conducted on 100 patients, who presented for bilateral extraction of mandibular impacted third molars. Group I included 50 patients who were subjected to L-PRF, and group II included 50 patients who were subjected to L-PRF with β-TCP in the extracted socket after removal of the mandibular third molar. The surgical site bleeding was assessed intraoperatively. The pain, swelling, and trismus were evaluated on the 1 Results: Group II patients experienced reduced surgical site bleeding, less postoperative swelling, maximum mouth opening, and improved bone regeneration ( Conclusion: The results of our study indicate that L-PRF combined with β-TCP remains an excellent and promising biocompatible material for achieving better postoperative outcomes compared to L-PRF alone.
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