ArticleJournal of dental sciences2026
Development of ion-loaded polyethylene glycol-based biomaterials for the controlled mineral occlusion and antibacterial sealing in dentinal tubules.
Article in Journal of dental sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Background/purpose: Dentinal tubule exposure leads to dentin hypersensitivity and pulp bacterial invasion. This study aimed to evaluate polyethylene glycol (PEG) derivatives, varying in different molecular weights (MWs) and functional groups, to achieve deep dentinal tubule occlusion and concurrent antimicrobial activity under the neutral, nondestructive conditions. Materials and methods: PEG derivatives were synthesized, ion-loaded, and characterized. Results: Low MW PEG exhibited ideal nanoscopic size and charge neutrality. Both MW and functional group modifications affected ion permeation and controlled crystallization. Among the materials, PEG Conclusion: PEG derivatives with low MW are the most promising candidates, demonstrating excellent biocompatibility and deep dentinal tubule sealing via strontium phosphate-related crystallization under the neutral conditions. While functional groups like AAC offer superior crystal control and antibacterial properties, the associated reduced penetration depth and cytotoxicity necessitate further optimization for clinical application.
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