ArticleJournal of dental sciences2026
Spatially resolved transcriptomics identifies epithelial-specific oncogenic signaling networks in ameloblastoma.
Article in Journal of dental sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background/purpose: Ameloblastoma is a benign odontogenic tumor characterized by locally aggressive growth and a high recurrence rate. Although recurrent mutations such as Materials and methods: An integrative transcriptomic strategy was applied, combining bulk RNA sequencing of fresh ameloblastoma and dental follicular tissues, RNA sequencing of primary cultured ameloblastoma epithelial cells and dental follicular epithelial cells, and spatial transcriptomic profiling of formalin-fixed, paraffin-embedded ameloblastoma specimens. Results: Differential expression and functional enrichment analyses identified 871 upregulated and 1464 downregulated genes in tumor tissues, and 360 upregulated and 306 downregulated genes in primary epithelial cells. Integration of these datasets defined a high-confidence set of 75 consistently dysregulated epithelial genes, including Conclusion: Together, these findings provide a refined molecular characterization of ameloblastoma and demonstrate spatially localized activation of multiple oncogenic signaling pathways within tumor epithelium, extending current single-pathway models of ameloblastoma pathogenesis and supporting the potential development of pathway-based or combinatorial therapeutic strategies.
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