ReviewNeurotrauma reports
Pre-Clinical and Clinical Therapies for Traumatic Brain Injury: Where Do We Stand in Pediatrics?
Review in Neurotrauma reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic brain injury (TBI) is one of the leading causes of death and disability in children. There are no Food and Drug Administration-approved therapies to specifically treat pediatric TBI. Compared with adults, there has been limited funding and investigation into age-specific injury patterns and therapies following trauma to the developing brain. This review summarizes therapies on early pathogenic mechanisms of secondary injury, specifically excitotoxicity, mitochondrial dysfunction and oxidative injury and neuroinflammation, which have been evaluated in pre-clinical and clinical moderate to severe pediatric TBI studies. We highlight areas in need of further research and suggest future directions for improving the bench-to-bedside translational therapeutic trials following pediatric TBI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.