ArticleJournal of dental sciences2026
The utility of 3D nanostructured polyglycolic acid fibers for novel bone regenerative medicine.
Article in Journal of dental sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/purpose: Autologous and artificial bone grafts are widely applied for alveolar bone reconstruction. However, as concerns regarding invasiveness, safety, and efficacy persist, the improved novel regenerative materials are expected. This study focuses on the bone regenerative potential of three-dimensional (3D) nanofiber-based polyglycolic acid (nPGA), whose capacity for bone regeneration remains unclear. Materials and methods: Four types of 3D PGA fibrous matrices with different fiber diameters and surface densities were used. The cell affinity, proliferative capacity, and osteogenic differentiation potential of the nPGA matrices were evaluated using human dental pulp stem cells (DPSCs). The effects of nPGA on bone regeneration were also investigated using an in vivo rat calvarial bone defect model. Results: The cellular responses to the PGA matrix clearly differed depending on the structural properties of the PGA fibers. Cell engraftment was significantly enhanced in the nPGA group compared to the conventional PGA group. DPSCs exhibited a time-dependent proliferation on the nPGA matrices. Scanning electron microscopy revealed cellular extensions aligned along the 3D microfiber architecture. Moreover, the osteoinductive assays demonstrated that DPSCs possessed osteogenic differentiation potential on nPGA scaffolds. Histological evaluation revealed new bone formation in the nPGA-transplanted group. Immunohistochemical staining of CD31 demonstrated that neovascularization also occurred adjacent to the newly formed bone in this group. Conclusion: The 3D nPGA matrix characterized by finer fibers and low surface density exhibited a remarkable cell affinity and an effective scaffold function in osteogenesis, suggesting that it could be useful as a novel medical material in bone regenerative medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.