Evidence map›Paper›PMID 42688636›Full record

ArticleJournal of dental sciences2026

Oral pathogens reprogram endothelial barrier and angiotensin-converting enzyme2/endothelial nitric oxide synthase-nitric oxide signaling to promote blood pressure dysregulation.

Ming-Shou Hsieh, Tung-Nien Hsu, Chin-Sheng Huang, Ting-Yi Renn, Kuang-Tai Kuo, Kuo-Yao Lin, Wei Jen Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ming-Shou Hsieh *School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Tung-Nien Hsu *School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Chin-Sheng HuangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Ting-Yi RennSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Kuang-Tai KuoDivision of Thoracic Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Kuo-Yao LinSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Wei Jen ChangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/purpose: Although periodontal disease is associated with an increased risk of hypertension, the endothelial mechanisms linking oral inflammation to vascular dysfunction remain unclear. We investigated whether Materials and methods: Human umbilical vein endothelial cells (HUVECs) were exposed to Results: Conclusion:

Indexed as

ACE2/eNOS/NOBlood pressureEndothelial dysfunctionMacrophage —endothelial crosstalkPorphyromonas gingivalis lipopolysaccharideRho/ROCK

Identifiers

PMID42688636
PMCPMC13536346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.