ArticleBMJ public health2026
Changed frequency of enterovirus hospitalisations after change of polio vaccination scheme: a nation-wide cohort study from Denmark.
Article in BMJ public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: This study examined whether ending oral poliovirus vaccination (OPV) increased enterovirus (EV) associated hospitalizations in children. Inactivated poliovirus vaccination (IPV) protects against disease caused by poliovirus. In contrast to OPV, it does not provoke a mucosal defence. Therefore, it is hypothesised that IPV does not offer cross-protection against other EV infections. Methods: The prevalence and incidence of EV cases were estimated in three cohorts of Danish children. To address the historically sparse diagnosis and registration of EV, we trained supervised machine-learning models in 2017-2018 admission data, validated them against the 2015-2016 cohort and applied the final model to the period 1996-2014. The study was conducted using nation-wide Danish registries on hospital admissions in 1996-2018. Three cohorts of all children living in Denmark born between 1 January 1996 and 31 December 1998 (201 460 live births), 1 January 2000 and 31 December 2004 (325 825 live births) and between 1 January 2005 and 31 December 2007 (194 303 live births) were followed in hospital registers until age 12. The outcomes were the prevalence and incidence of EV cases in the three cohorts and the ratio of estimates between the OPV and IPV cohorts. Results: Among 201 460 live births in the OPV cohort, 178 EV cases were identified, corresponding to an incidence rate of 6.48 per 100 000 risk years. The incidence rates per 100 000 risk years were 10.64 and 13.81 in the IPV cohorts, with 460 and 326 EV cases, respectively. The incidence rate ratio was 1.64 (95% CI 1.38 to 1.95) and 2.13 (1.78 to 2.56) in the two IPV cohorts compared with the OPV cohort. Conclusion: Children born in Denmark after 2001 had significantly higher rates of EV-related hospitalisations, suggesting potential cross-protective effects of OPV for EV-related hospitalisations. While supporting the hypothesis, the results should not be seen as risk attribution estimates, as the residual impact of diagnostic improvements is unmeasured.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.