ArticleFrontiers in molecular biosciences2026
Functional characterisation of PREL-1 and PREL-3 proteins as putative intramitochondrial phospholipid transporters governing homeostasis and organismal health in
Article in Frontiers in molecular biosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Mitochondrial phospholipids are crucial for maintaining structure and function; however, their roles and transport pathways are not fully understood in a multicellular model organism. In this study, we examined two putative Methods: Results: Docking studies predicted that phosphatidic acid (PA) preferentially binds to PREL-1 compared to PREL-3. Mitochondrial profiling revealed loss of mitochondrial phospholipid homeostasis upon RNAi knockdown. This resulted in mitochondrial dysfunction leading to impaired reproduction, respiration, locomotion, and elevated ROS levels in worms lacking these phospholipid transporters. Conclusion: Our findings support the role of PREL-1 and PREL-3 proteins in mitochondrial phospholipid homeostasis and suggest their function as PRELI- family phospholipid transporters. This study demonstrates the importance of these phospholipid transporters in mitochondrial function, growth, lifespan, and organism physiology.
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