ArticleMedComm2026
Antitumor Activity of Combined Topoisomerase Inhibition and FLASH Radiotherapy in Head and Neck Carcinoma Biomodels.
Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Locally advanced head and neck carcinoma remains associated with high morbidity and long-term survival below 50%. Treatment commonly relies on cisplatin-based chemoradiotherapy, which is effective but frequently associated with significant acute and chronic systemic toxicities. Therefore, safer and more effective therapeutic strategies are urgently needed. FLASH radiotherapy (RT) has emerged as a promising irradiation modality because of its potential to reduce damage to healthy tissues while preserving antitumor efficacy. Here, we investigated the anticancer activity of the Topoisomerase (Topo)-II inhibitor ARN-24139, alone and combined with FLASHRT, in human papillomavirus-negative SCC-25 head and neck carcinoma biomodels. Antitumor activity was assessed in 2D cell cultures using viability, apoptosis, clonogenic, wound-healing, and γH2AX assays, as well as in SCC-25 3D spheroids and in chorioallantoic membrane (CAM) tumor models. ARN-24139 induced dose-dependent cytotoxicity in SCC-25 cells, with IC
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.