SynthesisFrontiers in nutrition2026
Effects of oral fenugreek-derived preparations on testosterone-related outcomes in adult men: a systematic review and meta-analysis of randomized placebo-controlled trials.
Synthesis in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Background: Fenugreek ( Objective: To systematically evaluate the effects of oral fenugreek-derived preparations on testosterone-axis outcomes in adult men and to descriptively summarize related male-health outcomes, including sexual function, symptoms, body composition, exercise performance, and safety. Methods: We included randomized placebo-controlled trials in adult men that evaluated oral fenugreek-derived preparations. Two authors independently searched PubMed, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, and Scopus from inception to May 11, 2026, and additionally searched ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform (WHO ICTRP) for unpublished or grey evidence. Total testosterone and free testosterone were the primary outcomes. Risk of bias was assessed with the Cochrane Risk of Bias 2 (RoB 2) tool, certainty of evidence was graded using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, and the main pooled estimates were synthesized as standardized mean differences (SMDs) using random-effects models with restricted maximum likelihood (REML) estimation. Results: Thirteen studies were included, of which eight reported primary testosterone-axis data and five provided related or contextual male-health evidence. Six studies contributed to the total-testosterone meta-analysis, which showed a small favorable association with fenugreek (SMD: 0.25, 95% CI: 0.02, 0.48; Conclusion: Oral fenugreek-derived preparations may be associated with a small favorable standardized effect on total testosterone in adult men, but the evidence is very uncertain and does not demonstrate a stable free-testosterone benefit. Current evidence does not support clinical or commercial testosterone-boosting claims. Systematic review registration: PROSPERO registration number: CRD420261364708. https://www.crd.york.ac.uk/PROSPERO/view/CRD420261364708.
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