ArticleSAGE open medical case reports2026
The value of adrenal venous sampling in unveiling the conundrum of double unilateral adrenal adenomas in a case of primary hyperaldosteronism.
Article in SAGE open medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Primary hyperaldosteronism (PHA) is a cause of secondary hypertension, often due to adrenal adenoma. The diagnosis and management of multiple unilateral adrenal adenomas in PHA represent a unique challenge. Adrenal venous sampling (AVS) has become a pivotal diagnostic tool in these cases, providing critical information for accurate localization of aldosterone production. Here, we describe a rare case of a 52-year-old female with a history of resistant essential hypertension who presented with multiple unilateral adrenal adenomas concomitant with adrenal hyperplasia in a case of primary hyperaldosteronism. The use of AVS in localization of aldosterone production was the determining factor in deciding the ultimate management of the patient, leading to successful follow-up on medical therapy with spironolactone.
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