ArticleAnesthesiology research and practice2026
Effect of Low-Dose Propofol Administered at the End of Sevoflurane Anesthesia on Emergence Agitation in Pediatric Patients Undergoing MRI: A Randomized Controlled Trial.
Article in Anesthesiology research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Emergence agitation (EA) is a common postanesthetic problem in pediatric patients, particularly with sevoflurane anesthesia, and may lead to injury to patients, prolonged postanesthesia care unit (PACU) stay, and a risk of long-term maladaptive behavioral changes. Evidence regarding EA in nonpainful procedures such as magnetic resonance imaging (MRI) remains inconclusive. This study evaluated the effect of low-dose propofol at the end of sevoflurane anesthesia on EA in pediatric patients undergoing MRI. Methods: In this randomized controlled trial, 130 pediatric patients aged 2-8 years undergoing MRI under sevoflurane anesthesia with a laryngeal mask airway were enrolled. Patients were randomly assigned to receive either Group P ( Results: In the per-protocol analysis ( Conclusions: Administration of propofol at a dose of 0.5 mg/kg at the end of sevoflurane anesthesia significantly reduces EA in pediatric patients undergoing MRI without prolonging recovery or increasing adverse events. Further large-scale, multicenter studies are warranted to confirm efficacy and evaluate safety.
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