ArticleClinical case reports2026
Squamous Cell Carcinoma Arising in a Mature Cystic Teratoma of the Ovary Presenting With a Ruptured Sister Mary Joseph Nodule: A Rare Case Report From Northern Tanzania.
Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Squamous cell carcinoma arising from malignant transformation of a mature cystic teratoma is an exceptionally rare ovarian malignancy, and metastatic umbilical involvement is particularly uncommon. Diagnosis and treatment planning are challenging due to overlapping presentation with epithelial ovarian cancer, particularly in settings with limited access to ancillary pathology, molecular testing, and specialist oncology services. We report a 54-year-old postmenopausal woman from northern Tanzania who presented with progressive abdominal distension and a spontaneously ruptured umbilical lesion with persistent discharge. Contrast-enhanced computed tomography demonstrated a large complex right adnexal mass with calcifications and enhancing solid components, necrotic pelvic lymphadenopathy, peritoneal disease, and an umbilical lesion consistent with a Sister Mary Joseph nodule. Following multidisciplinary discussion and consideration of local diagnostic and financial constraints, she underwent exploratory laparotomy, total abdominal hysterectomy, bilateral salpingo-oophorectomy, infracolic omentectomy, and wide excision of the umbilical lesion. Complete cytoreduction was not feasible due to unresectable rectal serosal and diffuse peritoneal disease. Histopathologic examination demonstrated well-differentiated invasive squamous cell carcinoma arising within a mature cystic teratoma, with metastatic involvement of the omentum and umbilical skin. No cervical, uterine, or contralateral adnexal primary malignancy was identified. Immunohistochemistry was not performed because of limited local availability and cost; however, residual mature teratomatous elements adjacent to invasive keratinizing squamous cell carcinoma supported the diagnosis. She initiated adjuvant carboplatin-paclitaxel chemotherapy following uneventful postoperative recovery. This case illustrates an unusual presentation of malignant transformation of mature cystic teratoma with cutaneous metastasis in a resource-limited setting.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.