Age-stratified mutation patterns in early-onset colorectal cancer reveal distinct molecular features and therapeutic implications.

L Liu, A Rose, A Samaddar, B M Ascherman, J Levenson, T J Brown, U S Grewal, N J Hornstein

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Article in ESMO gastrointestinal oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

L LiuDepartment of Internal Medicine, Northwell Health Lenox Hill Hospital, New York, USA.

A RoseDepartment of Internal Medicine, Northwell Health Lenox Hill Hospital, New York, USA.

A SamaddarDepartment of Internal Medicine, Northwell Health NSLIJ, Manhasset, USA.

B M AschermanNorthwell Health Cancer Institute, New York, USA.

J LevensonNorthwell Health Cancer Institute, New York, USA.

T J BrownSimmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, USA.

U S GrewalWinship Cancer Institute of Emory University, Atlanta, USA.

N J HornsteinDepartment of Internal Medicine, Northwell Health Lenox Hill Hospital, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Colorectal cancer (CRC) is increasingly diagnosed in younger adults, with evidence that early-onset cases (age <50 years) differ in the spectrum of prevalent gene mutations compared with older individuals. To evaluate how these age-related differences may inform testing guidelines and therapeutic development, we examined mutation rates of the most prevalent gene mutations across four age-stratified cohorts. Patients and methods: Clinicogenomic data were obtained from Memorial Sloan Kettering Center for Harmonized Onco-genomic Research Dataset and China Pan-Cancer cohorts available in cBioPortal. A total of 6762 samples were analyzed. Mutation frequencies for a comprehensive panel of the 100 most prevalent CRC genes were compared across four age groups: 18-29 ( Results: Statistically significant variation in mutation frequency across age groups was seen in 22 key genes. Conclusions: Differences in mutations of key genes including a lower prevalence of

Indexed as

age-associated mutation patternsAPCearly-onset colorectal cancerPOLESMAD4

Identifiers

PMID42688374

DOI10.1016/j.esmogo.2026.100400

PMCPMC13534847

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