Evidence map›Paper›PMID 42688299›Full record

ArticleFrontiers in transplantation2026

Prolonged

Justin Issard, Julia Mercier, Jean-Baptiste Ménager, Guillaume Fadel, Yuya Nobori, Melwan Izem, Maria-Rosa Ghigna, Elie Fadel, Fabrice Antigny, Pierre Mordant and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Justin IssardDepartment of Thoracic Surgery and Heart-Lung Transplantation, Marie Lannelongue Hospital, Université Paris-Saclay, Le Plessis Robinson, France.
Julia MercierHypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), Hôpital Bicêtre (AP-HP), Hôpital Marie Lannelongue, FHU André Cournand, ERN-LUNG, Université Paris-Saclay, INSERM UMR_S 1358, Le Plessis Robinson, Le Kremlin-Bicêtre, France.
Jean-Baptiste MénagerDepartment of Thoracic Surgery and Heart-Lung Transplantation, Marie Lannelongue Hospital, Université Paris-Saclay, Le Plessis Robinson, France.
Guillaume FadelDepartment of Thoracic Surgery and Heart-Lung Transplantation, Marie Lannelongue Hospital, Université Paris-Saclay, Le Plessis Robinson, France.
Yuya NoboriHypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), Hôpital Bicêtre (AP-HP), Hôpital Marie Lannelongue, FHU André Cournand, ERN-LUNG, Université Paris-Saclay, INSERM UMR_S 1358, Le Plessis Robinson, Le Kremlin-Bicêtre, France.
Melwan IzemHypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), Hôpital Bicêtre (AP-HP), Hôpital Marie Lannelongue, FHU André Cournand, ERN-LUNG, Université Paris-Saclay, INSERM UMR_S 1358, Le Plessis Robinson, Le Kremlin-Bicêtre, France.
Maria-Rosa GhignaDepartment of Pathology, Marie Lannelongue Hospital, Groupe Hospitalier Paris-Saint-Joseph, Le Plessis Robinson, France.
Elie FadelDepartment of Thoracic Surgery and Heart-Lung Transplantation, Marie Lannelongue Hospital, Université Paris-Saclay, Le Plessis Robinson, France.
Fabrice AntignyHypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), Hôpital Bicêtre (AP-HP), Hôpital Marie Lannelongue, FHU André Cournand, ERN-LUNG, Université Paris-Saclay, INSERM UMR_S 1358, Le Plessis Robinson, Le Kremlin-Bicêtre, France.
Pierre MordantDepartment of Thoracic and Vascular Surgery and Lung Transplantation, Bichat Hospital, Assistance-Publique des Hôpitaux de Paris, Paris, France.
Olaf MercierDepartment of Thoracic Surgery and Heart-Lung Transplantation, Marie Lannelongue Hospital, Université Paris-Saclay, Le Plessis Robinson, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: During Methods: Twelve porcine lung blocks were harvested and cold-preserved before undergoing 12 h of normothermic EVLP. Lung blocks were randomly assigned to two groups based on the perfusate replacement strategy. All lungs were perfused with Steen solution, mean priming volume was 1,525 ± 340 and 1,325 ± 232 mL, with 100 mL (5%-9%) replaced every two hours by either fresh Steen solution (standard group, Results: Perfusate correction successfully maintained electrolyte, pH, and glucose levels within target ranges during EVLP. The corrected group demonstrated higher lung compliance and oxygenation, reduced edema, more hyaline membranes, and a greater density of Kohn's pores after EVLP. PVR was similar between groups, and no significant difference in Conclusion: Maintaining physiological perfusate composition improved lung function during 12-hour EVLP in swine; however, no post-transplant benefit was observed. Further studies are warranted to assess the impact of this strategy during prolonged EVLP and to compare it with alternative approaches.

Indexed as

EVLPEVLP durationlung transplant (LTx)pig modelpreclinical (in vivo) studiesprolonged EVLP

Identifiers

PMID42688299
PMCPMC13533982

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.