ArticleFrontiers in bioengineering and biotechnology2026
Shape predicts osteoarthritis progression in the first carpometacarpal joint.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Introduction: Statistical shape modelling enables global geometric features of bones to be quantified and previously has demonstrated differences between healthy and osteoarthritic populations, including at the first carpometacarpal (CMC) joint. However, no study has examined how the variability in the shapes of the metacarpal and trapezium change with time. The aim of this study was to determine if baseline morphological differences in the first metacarpal and trapezium distinguish individuals with progressive first CMC joint osteoarthritis (OA) from non-progressors. It was hypothesized that distinct morphological differences exist in these bones between participants with first CMC joint OA who experience disease progression and those who do not. Methods: Longitudinal three-dimensional (3D) meshes from 85 osteoarthritic first carpometacarpal (CMC) joints (46 females and 39 males; 57.3 ± 8.4 years) were categorized as non-progressors (n = 49) or progressors (n = 36). Statistical shape modelling quantified morphological changes between baseline and follow-up (1.5 or 6 years) scans for the first metacarpal and trapezium. A non-parametric combination test was used to identify significant morphological differences between time-points. Results: Morphological differences were identified in both the first metacarpal and trapezium between participants with OA of the first CMC joint that progressed and those that did not. On the first metacarpal, the articulation surface tilt angle and protrusion at the volar beak were two morphological parameters that differed between the progressor and non-progressor groups. On the trapezium, depressions at the volar and radial regions of the articulating surface, and protrusions at the radial and ulnar borders of the carpometacarpal facet were indicated by the shape models for the progressor group. Discussion: These findings may be used to stratify treatment approaches for CMC joint OA, avoiding unnecessary interventions for those who are unlikely to experience disease progression, while monitoring those who are more likely to experience progression more closely.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.