ArticleFrontiers in aging neuroscience2026
Cell-type-dependent decline of IGF1 and IGF1R in the prefrontal cortex contributes to age-related behavioral changes.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Insulin-like growth factor 1 (IGF1) signaling plays a critical role in brain function and declines significantly with aging. However, how these changes occur across different brain regions and cell types, and how they contribute to behavioral dysfunction, remains poorly understood. The prefrontal cortex (PFC), a key regulator of cognitive, emotional, and social behaviors, is particularly vulnerable to age-related changes. Here, we investigated age-associated changes in IGF1 and its receptor (IGF1R) in major neuronal populations of the PFC and examined their functional relevance. Using immunohistochemical analysis across young adult, middle-aged, and aged mice, we identified cell-type-dependent alterations in IGF1 and IGF1R expressions in the PFC of C57BL/6 mice, characterized by a reduction of IGF1 in both excitatory (CaMKII
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