Evidence map›Paper›PMID 42688200›Full record

Observational studyFrontiers in immunology2026

Epidermal growth factor receptor and myeloperoxidase expression in geographic tongue: an observational study.

Amal Dafar, Anna-Karin Östberg, Asal Shikhan, Lena Larsson, Mats Jontell, Hülya Cevik-Aras

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amal DafarDepartment of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Anna-Karin ÖstbergDepartment of Oral Microbiology and Immunology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Asal ShikhanDepartment of Periodontology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Lena LarssonDepartment of Periodontology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Mats JontellDepartment of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Hülya Cevik-ArasDepartment of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Geographic tongue (GT) is a common oral mucosal lesion that affects the dorsal and lateral surfaces of the tongue and characterized by erythematous areas of papillary atrophy surrounded by peripheral zones. The aim of this study was to evaluate the expression of myeloperoxidase (MPO), epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) in tissue samples from patients with GT compared to control. Methods: Biopsies specimens from patients with GT (n=10, mean age 48.3 ± 16.7 years) and control subjects (n=3, mean age 59.0 ± 3 years) were evaluated. Immunofluorescence was used to assess the MPO staining intensity of positive cells (i.e. scoring grades 0, 1 and 2). Furthermore, the percentage of EFG and EGFR positive cells in the tongue tissue samples was evaluated by immunofluorescence. Results: Most of the patients with GT (n=6) scored 2 for MPO expression, demonstrating an increased expression of MPO among GT patients compared to controls ( Conclusion: Patients with GT showed a high MPO activity while low EGFR expression which may explain the underlying inflammatory response and decreased regeneration process in GT.

Indexed as

ErbB ReceptorsGlossitis, Benign MigratoryPeroxidaseTongueAdultAgedBiopsyEpidermal Growth FactorFemaleHumansMaleMiddle AgedEGFR protein, humanEpidermal Growth FactorErbB ReceptorsMPO protein, humanPeroxidasebenign migratory glossitisgrowth factorsmyeloperoxidaseoral diseasesoral mucosal lesionstongue lesions

Identifiers

PMID42688200
PMCPMC13534091

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.