ArticleFrontiers in cellular and infection microbiology2026
Risk factors for prolonged hospitalization and disease course in osteomyelitis: a single-centre cohort study.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate pathogen epidemiology and clinical characteristics in osteomyelitis patients for optimizing clinical management strategies. Methods: Confirmed osteomyelitis cases required pathogen isolation with radiological correlation. The cohort included both confirmed (culture-positive) and probable (culture-negative but meeting clinical and radiological criteria) cases, Radiation-induced osteomyelitis, sclerosing osteomyelitis and drug-associated osteomyelitis. Clinical specimens underwent standardized culture and VITEK Compact II or MALDI-TOF MS identification. SPSS 22.0 analyzed data via Mann-Whitney U tests and logistic regression for prolonged outcomes. Results: Analysis of 704 osteomyelitis patients revealed a male predominance (2.5:1 ratio) with median age at presentation of 41.4 years (IQR 27.0-55.0). Mortality was low (0.7%), but disability/amputation occurred in 3.53%. Patients experienced median cumulative hospitalization of 22 days (IQR 15.0-38.2) and disease duration of 4.7 months (IQR 1.5-13.6), with 79.7% undergoing surgical intervention (primarily lesion resection [22.7%] or debridement [14.2%]). The tibia was the most frequent infection site (31.5%), followed by femur (18.4%) and Jawbone (9.7%). Fracture-related infections predominated pathogenetically (47.7%), showing tibial (47.3%) and femoral (23.8%) predominance with Conclusion: In conclusion, fracture, femur involvement,
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