Evidence map›Paper›PMID 42688089›Full record

ArticleFrontiers in microbiology2026

HP1581 (WecA)-dependent O-antigen biosynthesis governs adhesion, virulence, and biofilm dynamics in

Tram Thi Hong Nguyen, Mamoona Hassan, Kai-Wen Teng, Steffen Backert, Song-Wei Wang, Chung-Jung Liu, Deng-Chyang Wu, Chao-Hung Kuo, Mou-Chieh Kao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tram Thi Hong Nguyen *Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan.
Mamoona Hassan *Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan.
Kai-Wen TengInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan.
Steffen BackertDivision of Microbiology, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Song-Wei WangDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Chung-Jung LiuDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Deng-Chyang WuDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Chao-Hung KuoDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Mou-Chieh KaoInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: An Results: Disruption of Conclusion: HP1581 (WecA) is essential for O-antigen biosynthesis and plays critical roles in maintaining outer membrane integrity, regulating bacterial surface properties, promoting host cell interactions, modulating virulence-associated factors, and influencing biofilm development. These findings identify HP1581 (WecA)-dependent O-antigen biosynthesis as a key determinant of

Indexed as

bacterial adhesionbiofilm formationHelicobacter pyloriHP1581 (WecA)lipopolysaccharideO-antigen biosynthesisouter membrane vesiclesvirulence

Identifiers

PMID42688089
PMCPMC13533946

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.