Evidence map›Paper›PMID 42688080›Full record

ArticleFrontiers in immunology2026

Effect of anakinra on cytokine storm during sepsis-induced multiple organ dysfunction syndrome: case report and preclinical investigation.

Rebecca M Blade, Sarah P Lecher, Todd M Umstead, Zissis C Chroneos, Cainan Riccio-Baum, S Rameeza Allie, Timothy J Hahn, Daniel J McKeone, Jessica E Ericson, Theodore DeMartini and 2 more

Abstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rebecca M BladeDepartment of Pediatrics, Penn State College of Medicine, Hershey, PA, United States.
Sarah P LecherDivision of Pediatric Critical Care Medicine, Penn State College of Medicine, Hershey, PA, United States.
Todd M UmsteadDepartment of Pediatrics, Penn State College of Medicine, Hershey, PA, United States.
Zissis C ChroneosPulmonary Immunology and Physiology Laboratory, Penn State College of Medicine, Hershey, PA, United States.
Cainan Riccio-BaumDepartment of Cell and Biological Systems, Penn State College of Medicine, Hershey, PA, United States.
S Rameeza AllieDepartment of Cell and Biological Systems, Penn State College of Medicine, Hershey, PA, United States.
Timothy J HahnDivision of Pediatric Rheumatology, Penn State College of Medicine, Hershey, PA, United States.
Daniel J McKeoneDysregulated Immune Response Team (DIRT), Penn State College of Medicine, Hershey, PA, United States.
Jessica E EricsonDysregulated Immune Response Team (DIRT), Penn State College of Medicine, Hershey, PA, United States.
Theodore DeMartiniDivision of Pediatric Critical Care Medicine, Penn State College of Medicine, Hershey, PA, United States.
Debbie SpearDivision of Pediatric Critical Care Medicine, Penn State College of Medicine, Hershey, PA, United States.
E Scott HalsteadDivision of Pediatric Critical Care Medicine, Penn State College of Medicine, Hershey, PA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe the case of a young female who presented with apparent human metapneumovirus-associated illness and dehydration, but whose condition rapidly worsened with progression to multiple organ dysfunction syndrome (MODS). Multiple modalities were used to treat the patient, including: 1) extracorporeal life support (ECLS) for refractory shock; 2) anakinra, a human recombinant interleukin (IL)-1 receptor antagonist, for presumed cytokine storm; and 3) therapeutic plasma exchange (TPE) for thrombocytopenia-associated multiple organ failure (TAMOF). The patient's organ dysfunction rapidly improved.

Indexed as

Cytokine Release SyndromeInterleukin 1 Receptor Antagonist ProteinMultiple Organ FailureSepsisAdultAnimalsCytokinesFemaleHumansCytokinesInterleukin 1 Receptor Antagonist Proteinanakinracytokine storm syndromeHLHMASMODSsepsis

Identifiers

PMID42688080
PMCPMC13533806

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.