ArticleFrontiers in physiology2026
Serum calcium-magnesium-phosphate-potassium metabolic dysregulation in nephrolithiasis: predictive model development and mechanistic insights.
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To explore the pathophysiological interplay of serum calcium, magnesium, phosphate, and potassium (Ca, Mg, P, K) homeostasis in nephrolithiasis and establish an integrated risk prediction framework incorporating these routine homeostatic biomarkers. Methods: This retrospective, hospital-based case-control study enrolled 611 patients with radiologically confirmed nephrolithiasis and 624 strict gender-matched controls to eliminate sex-related baseline biases. Fasting morning serum biochemical data were analyzed. Multivariable logistic regression identified core risk determinants. Model performance was rigorously validated through receiver operating characteristic (ROC) analysis, calibration curves, and decision curve analysis (DCA), followed by the construction of a diagnostic nomogram. Results: The predictive model based on electrolyte indices demonstrated exceptional discriminative capacity (AUC = 0.812, 95% CI: 0.789-0.836) and high calibration accuracy (Brier score = 0.177, Hosmer-Lemeshow p = 0.852). Key independent predictors included an elevated serum calcium magnesium ratio (Ca/Mg, aOR = 5.50), increased calcium phosphate product (Ca×IP, aOR = 1.82), hypokalemia (aOR = 0.13), BMI ≥ 24, and reduced hemoglobin levels. DCA confirmed the model's net clinical benefit across a wide range of threshold probabilities. Conclusion: Dysregulation of serum Ca, Mg, P, K homeostasis is strongly associated with nephrolithiasis. Our nomogram may offer a complementary, blood-based initial assessment when 24-hour urine testing is not feasible, pending further validation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.