ArticleFrontiers in endocrinology2026
Comparative associations of the TyG index and METS-IR with arterial stiffness in women: a cross-sectional analysis by menopausal status.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To compare the cross-sectional associations of the triglyceride-glucose (TyG) index and the metabolic score for insulin resistance (METS-IR) with brachial-ankle pulse wave velocity (baPWV) in women and to examine whether these associations differed by menopausal status. Methods: This cross-sectional secondary analysis included 306 women (134 premenopausal and 172 postmenopausal). baPWV was analyzed as a continuous measure of arterial stiffness. Associations with TyG and METS-IR were examined using Pearson correlation, restricted cubic splines, and multivariable linear regression; the primary adjusted model included age, menopausal status, systolic blood pressure, uric acid, LDL-C, and eGFR and omitted BMI because BMI is a component of METS-IR. Exploratory ROC analyses compared the discrimination of covariate-adjusted TyG and METS-IR models for elevated baPWV (≥1400 cm/s) using the DeLong test. Sensitivity and menopausal-status subgroup analyses were also performed. Results: Both METS-IR and TyG were positively correlated with baPWV in unadjusted analyses. After adjustment for menopausal status, age, SBP, uric acid, LDL-C, and eGFR, METS-IR remained associated with baPWV (β = 4.72, 95% CI 1.03-8.41, P = 0.012), whereas TyG did not (β = 26.66, 95% CI -11.49-64.81, P = 0.170). In stratified analyses, METS-IR was associated with baPWV in postmenopausal women (β = 5.68, 95% CI 0.74-10.61, P = 0.025) but not in premenopausal women (β = 4.16, 95% CI -1.22-9.53, P = 0.128); however, the interaction was not significant (P for interaction = 0.722). The TyG and METS-IR models showed similar exploratory discrimination for elevated arterial stiffness (AUC 0.831 Conclusion: In this cross-sectional dataset of women, METS-IR retained an adjusted association with baPWV, whereas the corresponding association for TyG was not statistically significant. Menopausal status did not significantly modify either association. The TyG and METS-IR models showed similar exploratory discrimination for elevated baPWV. Prospective external studies are needed to assess temporal associations and clinical utility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.