Evidence map›Paper›PMID 42688002›Full record

ArticleFrontiers in cellular and infection microbiology2026

Cutaneous papillomaviruses infection rewires fatty-acid metabolism.

Xiaoyan Liu, Dan Li, Fangzhou Cai, Yan Li, Wei Wang, Junhua Liao, Shijun Shan

Abstract read
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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoyan Liu *Department of Dermatology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Dan Li *National Center of Technology Innovation for animal model. State Key Laboratory of Respiratory Health and Multimorbidity. Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of Education. NHC Key Laboratory of Comparative Medicine. Institute of Laboratory Animal Science, CAMS & PUMC, Beijing, China.
Fangzhou CaiNational Center of Technology Innovation for animal model. State Key Laboratory of Respiratory Health and Multimorbidity. Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of Education. NHC Key Laboratory of Comparative Medicine. Institute of Laboratory Animal Science, CAMS & PUMC, Beijing, China.
Yan LiDepartment of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Wei WangNational Center of Technology Innovation for animal model. State Key Laboratory of Respiratory Health and Multimorbidity. Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of Education. NHC Key Laboratory of Comparative Medicine. Institute of Laboratory Animal Science, CAMS & PUMC, Beijing, China.
Junhua LiaoUniversite Paris Dauphine, Paris, France.
Shijun ShanDepartment of Dermatology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cutaneous warts are common HPV-induced lesions with limited treatments for recalcitrant cases. Fatty-acid metabolism (FAM) maintains epidermal homeostasis, but whether papillomavirus infection actively suppresses FAM programs and whether restoring FAM-related regulators can modulate keratinocyte dysfunction remain unclear. Methods: We established a murine MmuPV1 wart model and performed bulk RNA-seq. FAM-related DEGs were identified via network analysis and machine learning. Immune infiltration was assessed by CIBERSORT. Results: Transcriptome analysis revealed significant suppression of FAM pathways in wart lesions. Four key FAM-related differentially expressed genes (Nr1h3, Dgat1, Scd1, and Fabp4) were identified from RNA-seq-based bioinformatic analyses and further supported by Conclusions: Papillomavirus infection is associated with coordinated suppression of FAM-related programs. NR1H3, Dgat1, Scd1, and Fabp4 represent candidate metabolic regulatory nodes; their therapeutic relevance requires further

Indexed as

Fatty AcidsHuman Papillomavirus VirusesPapillomavirus InfectionsAnimalsDiacylglycerol O-AcyltransferaseDisease Models, AnimalGene Expression ProfilingHumansKeratinocytesLiver X ReceptorsMiceOncogene Proteins, ViralRepressor ProteinsStearoyl-CoA DesaturaseDiacylglycerol O-AcyltransferaseE6 protein, Human papillomavirus type 16Fatty AcidsLiver X ReceptorsOncogene Proteins, ViralRepressor ProteinsStearoyl-CoA Desaturasecutaneous wartsfatty-acid metabolismimmune cell infiltrationpapillomavirus infectiontranscriptome analysis

Identifiers

PMID42688002
PMCPMC13533699

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.