Evidence map›Paper›PMID 42687991›Full record

ArticleResearch square2026

First

Valeria Narykina, Romy Cools, Niels Van Winnendael, Koen Vermeulen, Guy Bormans, Ludovic Le Saux

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Valeria NarykinaLaboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.
Romy CoolsLaboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.
Niels Van WinnendaelLaboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.
Koen VermeulenNuclear Medical Applications, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium.
Guy BormansLaboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.ORCID https://orcid.org/0000-0002-0335-7190
Ludovic Le SauxLaboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.ORCID https://orcid.org/0000-0002-2577-5297

Funding

Development of Hsp90 Isoform- Selective Inhibitors as a Novel Opioid Dose-Reduction TherapyR01DA052340 · NIDA · UNIVERSITY OF ARIZONA · PI STREICHER, JOHN MICHAEL · 2021 to 2025
$3.3M
Engineering the Next Generation of Safer Hsp90 InhibitorsR01CA270147 · NCI · UNIVERSITY OF NOTRE DAME · PI Brian S J Blagg, Mark Steven Cohen · 2023 to 2026
$1.8M
NCI NIH HHS R01 CA270147NIDA NIH HHS R01 DA052340
6 · The paper itself

Abstract

Background: Heat shock protein 90 (Hsp90) is a key molecular chaperone involved in maintaining proteostasis, and its function and aberrant expression are linked to tumour progression and to neurodegeneration. Its overexpression in cancers and the clinical development of Hsp90 inhibitors, including the recently approved pimitespib (TAS-116, trade name Jeselhy Results: [ Conclusions: [ Clinical trial number: not applicable.

Indexed as

[11C]OnalespibCancerdiagnosticglioblastomaheat shock proteinsPET radiotracer

Identifiers

PMID42687991
PMCPMC13533016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.