Evidence map›Paper›PMID 42687969›Full record

ArticleFrontiers in cellular neuroscience2026

Boldine treatment prevents chronic cognitive impairment and exaggerated fear learning in rats exposed to repetitive low-level blast injury.

Georgina Perez Garcia, Gissel M Perez, Rita De Gasperi, Miguel A Gama Sosa, Serena Yeung, Carolyn W Zhu, Patrick R Hof, Jiangping Pan, Shahrukh Khalique, Alexey Kozlenkov and 4 more

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Georgina Perez GarciaResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, United States.
Gissel M PerezResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, United States.
Rita De GasperiResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, United States.
Miguel A Gama SosaResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, United States.
Serena YeungResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, United States.
Carolyn W ZhuResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, United States.
Patrick R HofMount Sinai Alzheimer's Disease Research Center and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, United States.
Jiangping PanSpinal Cord Damage Research Center, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, United States.
Shahrukh KhaliqueSpinal Cord Damage Research Center, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, United States.
Alexey KozlenkovDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, United States.
Wei ZhaoSpinal Cord Damage Research Center, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, United States.
Carlos A ToroSpinal Cord Damage Research Center, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, United States.
Gregory A ElderDepartment of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, United States.
Christopher P CardozoSpinal Cord Damage Research Center, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, United States.

Funding

Research Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Margaret Sewell · 2020 to 2026
$31.0M
BLRD VA I01 BX005882NIA NIH HHS P30 AG066514RRD VA I01 RX003228RRD VA I01 RX003846RRD VA I21 RX004886
6 · The paper itself

Abstract

Many Veterans who experienced blast-related traumatic brain injuries (TBI) during their military service suffer from chronic cognitive and mental health problems including post-traumatic stress disorder (PTSD). Male rats exposed to repetitive low-level blast injuries designed to mimic the type of blast-related mild TBI that was so common in the conflicts in Iraq and Afghanistan develop delayed and persistent cognitive and PTSD-related traits that remain present for over 1 year after exposure. Boldine, an alkaloid derived from the Chilean Boldo tree (

Indexed as

blastboldinepost-traumatic stress disorderrattraumatic brain injury

Identifiers

PMID42687969
PMCPMC13533674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.