ArticleResearch square2026
Assessing Motion Fidelity During Closed-Head Rotational Acceleration Traumatic Brain Injury in Pigs.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Purpose: Traumatic brain injury (TBI) affects 69 million people annually and is most frequently caused by rapid rotational acceleration of the head. Modeling rotational acceleration injuries in pigs can employ biomechanical parameters scaled from humans, allowing researchers to answer basic and translational questions about the influence of injury kinematics on outcomes. However, precisely describing head kinematics during rotational acceleration injuries is imperative to understand the relationships between biomechanical parameters, pathology, and neurological outcomes. Methods: Using an established model of rapid rotational acceleration, we examined kinematic transfer efficiency by assessing how closely the motion of the subject's head matched the motion of the rotational device. Pigs were submitted to head rotation in the sagittal plane at either a moderate or a high target velocity. Kinematics were recorded with transducers and high frame rate videography, which was quantified manually and with the deep learning neural network, DeepLabCut. The rotational device was programmed to generate peak angular velocities ranging from 85.8-108.1 rad/s. Results: The kinematic coupling of the peak angular velocities between the head and transducer-mounted injury device was 95.30 ± 3.41% during moderate velocity TBIs and 93.09 ± 8.08% during high velocity TBI. Angular velocity exhibited strong matching between the head and injury device while angular acceleration exhibited fair-to-strong matching, depending on the kinematic term. These angular velocity and acceleration levels exceeded clinical injury thresholds from the literature based on appropriate mass scaling. Conclusions: The high degree of kinematic matching between injury device and head in both moderate and high velocity TBIs suggests a high kinematic transfer efficiency within the target range of angular velocities. This validation study provide critical insights into the fidelity of large animal rotational acceleration injury by enhancing our understanding of force transmission and head kinematics, leading to more accurate scaling and representation of human TBI events.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.