ArticleFrontiers in neurology2026
The architecture of quality of life after stroke: a network comparison of mild-to-moderate versus severe functional impairment.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Health-related quality of life (HRQoL) after stroke is multidimensional, yet conventional analyses often overlook the complex interactions among its domains and how these might differ by functional status. Objective: This study aimed to model and compare the network architecture of HRQoL between stroke survivors with mild-to-moderate versus severe functional dependence. Methods: In this multi-center cross-sectional study, 451 inpatients were assessed using the Stroke-Specific Quality of Life (SS-QOL) scale across 12 domains. Participants were stratified into a Mild-Moderate group (Barthel Index, BI > 40; Results: Although network structure did not differ significantly between groups ( Conclusion: The fundamental architecture of post-stroke HRQoL differs across levels of functional dependence. These findings support a precision rehabilitation framework: one targeting the synergy between physical functions in milder cases, and another focused on supporting cognitive integrity and social adaptation in severe disability.
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