ArticleResearch square2026
Detection of House Dust Mite-derived DNA in Human Lung Tumors by Whole-Genome Sequencing.
Sunandini Sharma, Tongwu Zhang, John McElderry, Olivia Lee, Phuc Hoang, Liping Zeng, Nicholas Webster, Ludmil Alexandrov, Eyal Raz, Maria Teresa Landi and 1 more
Abstract readPreprint
In one paragraphArticle in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Sunandini SharmaUniversity of California San Diego.
Tongwu ZhangNational Cancer Institute.
John McElderryNational Cancer Institute.
Olivia LeeNational Cancer Institute.
Phuc HoangNational Cancer Institute.
Liping ZengUniversity of California San Diego.
Nicholas WebsterUniversity of California San Diego.
Ludmil AlexandrovUniversity of California San Diego.
Eyal RazUniversity of California San Diego.
Maria Teresa LandiNational Cancer Institute.
Samuel BertinUniversity of California San Diego.
Funding
Studies of Genetic and Environmental EpidemiologyZIACP101231 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI LANDI, MARIA · 2018 to 2025
$23.6MRole of hypernutrition and metabolic stress in non-alcoholic steatohepatitis (NASH) driven hepatocellular carcinoma (HCC)P01CA281819 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Karin · 2024 to 2026
$9.2MRheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8MDetecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer PreventionR01ES032547 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDROV, LUDMIL B · 2021 to 2025
$3.4MMapping immuno-genomic drivers of the head and neck precancer invasive-disease transitionU01CA290479 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Jorge Silvio Gutkind · 2023 to 2026
$3.1MChronic Exposure to House Dust Mites: A New Risk Factor for Lung Cancer in Never SmokersU01CA276642 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Samuel P Bertin, Eyal Raz · 2023 to 2026
$2.4MComprehensive identification of germline-somatic interactionsR01CA269919 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Hannah Kathryn Carter · 2022 to 2026
$2.2MUnderstanding the origins of the mutational landscape in cancerR01ES036931 · NIEHS · UNIV OF ARKANSAS FOR MED SCIS · PI Ludmil B Alexandrov, Gunnar Boysen · 2025 to 2026
$1.5MExploring the Impact of Base Deaminase Deregulation on Precancer EvolutionR01CA296974 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Catriona Helen Macleod Jamieson · 2025 to 2026
$890kIntramural NIH HHS ZIA CP101231NCI NIH HHS P01 CA281819NCI NIH HHS R01 CA269919NCI NIH HHS R01 CA296974NCI NIH HHS U01 CA276642NCI NIH HHS U01 CA290479NIAMS NIH HHS T32 AR064194NIEHS NIH HHS R01 ES032547NIEHS NIH HHS R01 ES036931
6 · The paper itselfAbstract
Lung cancer in never-smokers (LCINS) accounts for an increasing proportion of lung cancer cases, yet its risk factors remain poorly understood. House dust mites (HDM) are common aeroallergens that induce airway inflammation, but their potential contribution to lung cancer is unknown. We analyzed unmapped whole-genome sequencing reads from 783 lung cancers from the Sherlock-
Indexed as
Environmental exposureHouse dust mitesLung cancerMicrobiomeTumor microenvironmentWhole-genome sequencing
Identifiers
PMID42687904
PMCPMC13532714
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