Evidence map›Paper›PMID 42687884›Full record

ArticleArXiv2026

Evaluation of the Exradin A30 Parallel Plate Ion Chamber as a Reference Dosimeter in Ultra-High Dose Rate (UHDR) Electron Beams.

Mervat Alharbi, Kevin Liu, Brian Hooten, Shannon Holmes, Stefanno Alarcon-Nunez, Jeffrey Radtke, Larry DeWerd, Sam Beddar, Wesley Culberson, Emil Schueler and 1 more

Abstract readPreprint
In one paragraph

Article in ArXiv, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mervat AlharbiDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
Kevin LiuDepartment of Radiation Physics Division of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Brian HootenStandard Imaging Inc, Middleton, WI.
Shannon HolmesStandard Imaging Inc, Middleton, WI.
Stefanno Alarcon-NunezDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
Jeffrey RadtkeDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
Larry DeWerdDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
Sam BeddarDepartment of Radiation Physics Division of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Wesley CulbersonDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
Emil SchuelerDepartment of Radiation Physics Division of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Ahtesham KhanDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
Research Supplements to Promote Diversity in Health-Related Research: Preclinical optimization of ultra-high dose rate (FLASH) radiotherapy parameters for translational relevanceR01CA266673 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SCHUELER, EMIL · 2022 to 2025
$3.5M
FY22 SBIR TOPIC 434 PHASE I - NOVEL NIST TRACEABLE IONIZATION CHAMBER FOR FLASH DOSIMETRY.75N91022C00039 · NCI · STANDARD IMAGING, INC. · PI HOLMES, SHANNON · 2022 to 2022
$400k
NCI NIH HHS 75N91022C00039NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA266673
6 · The paper itself

Abstract

Background: Establishing reliable reference dosimetry for ultra-high dose-rate (UHDR) beams (≥ 40 Gy/s) is challenging with conventional reference ionization chambers (IC) due to saturation effects arising from ion recombination. The Exradin A30 IC was introduced to overcome these challenges by utilizing an ultra-thin electrode spacing of 0.3 mm to enhance charge-collection efficiency (CCE). Purpose: The aim of this study is to investigate the commercial A30 IC as a reference dosimeter for UHDR electron beams. It explores the dosimetric properties of the A30 IC, including leakage current, CCE, polarity, and beam quality correction factors. Methods: Several measurements at the IntraOp Results: The A30 IC exhibited a leakage current of less than 2 fA. Both P Conclusions: The commercial A30 ionization chamber exhibited 5% recombination with DPP of up to 5 Gy in both distilled and saline water. The IC signal in a solid phantom was found to be dependent on charge buildup effects, which can be mitigated by utilizing grounded phantoms. When appropriate CCE corrections are applied, the A30 IC is a suitable reference dosimeter for UHDR electron beams.

Identifiers

PMID42687884
PMCPMC13532702

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.