Evidence map›Paper›PMID 42687767›Full record

ArticleDiabetes, obesity & metabolism2026

Use of Glucose-Lowering Drugs for Type 2 Diabetes Among Danish Care Home Residents.

Hanin Harbi, Reimar W Thomsen, Carina Lundby, Jacob Volmer Stidsen, Kurt Højlund, Jesper Ryg, Mette Reilev, Anton Pottegård

Abstract read
In one paragraph

Article in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hanin HarbiClinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0009-0004-3776-6541
Reimar W ThomsenDepartment of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-9135-3474
Carina LundbyClinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0002-2121-6252
Jacob Volmer StidsenSteno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
Kurt HøjlundSteno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.ORCID https://orcid.org/0000-0002-0891-4224
Jesper RygDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Mette ReilevClinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Anton PottegårdClinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0001-9314-5679

Funding

Novo Nordisk Foundation NNF17SA0030962-1
6 · The paper itself

Abstract

aimsCare home admission often reflects frailty and limited life expectancy, potentially altering the benefit-harm balance of glucose-lowering drug (GLD) treatment for type 2 diabetes (T2D). Real-world data on treatment patterns in this setting remain limited. We examined GLD use for T2D among Danish care home residents. MATERIALS AND

methodsWe conducted a nationwide, population-based drug utilisation study of all individuals admitted to Danish care homes between 2018 and 2023, using linked national health registries.

resultsAmong 88 658 residents (median age: 84 years [IQR: 78-90]; 60% women), 13% (n = 11 101) used GLDs for T2D at admission, with 84% continuing treatment beyond 2 years. Residents using GLDs at admission had long-standing diabetes (median duration: 12 years [IQR: 6.8-15]), relatively low glycated haemoglobin levels (median: 6.9% [IQR: 6.3-7.8]; 52 mmol/mol [45-62]) with little change around admission, and 43% used more than one GLD class, most commonly metformin (70%) and insulin (36%; basal: 30%; bolus: 16%). Use of glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors increased over time but remained limited (13% and 24%, respectively, in 2023), despite a high prevalence of cardiorenal disease (84%), and did not differ by cardiorenal disease status. Overall GLD use remained stable around admission, but initiation spiked 3 months before admission (36 initiators/10 000 residents), often following hospitalisation (63%) and primarily involved bolus insulin initiated by hospital physicians.

conclusionsGLD use for T2D among Danish care home residents is high and shows limited deintensification and potential misalignment with guideline recommendations.

Indexed as

Diabetes Mellitus, Type 2Hypoglycemic AgentsAgedAged, 80 and overDenmarkFemaleGlycated HemoglobinHumansInsulin SecretagoguesMaleMetforminNursing Home ResidentsRegistriesSodium-Glucose Transporter 2 InhibitorsGlycated HemoglobinHypoglycemic AgentsInsulin SecretagoguesMetforminSodium-Glucose Transporter 2 Inhibitorsantidiabetic drugpharmaco‐epidemiologyreal‐world evidencetype 2 diabetes

Identifiers

PMID42687767
PMCPMC13730979

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.