Evidence map›Paper›PMID 42687516›Full record

ArticleKorean journal of clinical oncology2026

Targetable genes associated with hematogenous metastasis in gastric cancer using the TCGA database.

Jaeun Yoo, Hyun Myong Kim, Kyoungyun Jeong, Yie-Ri Yoo, Ji-Yeon Shin, Seungho Lee, Seungbok Lee, Hye Seung Lee, Kyoung Un Park, Seong-Ho Kong and 3 more

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Article in Korean journal of clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Jaeun YooCancer Research Institute, Seoul National University, Seoul, Korea.
Hyun Myong KimCancer Research Institute, Seoul National University, Seoul, Korea.
Kyoungyun JeongCancer Research Institute, Seoul National University, Seoul, Korea.
Yie-Ri YooCancer Research Institute, Seoul National University, Seoul, Korea.
Ji-Yeon ShinCancer Research Institute, Seoul National University, Seoul, Korea.
Seungho LeeDepartment of Surgery, Seoul National University Hospital, Seoul, Korea.
Seungbok LeeDepartment of Surgery, Seoul National University Hospital, Seoul, Korea.
Hye Seung LeeCancer Research Institute, Seoul National University, Seoul, Korea.
Kyoung Un ParkDepartment of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Seong-Ho KongCancer Research Institute, Seoul National University, Seoul, Korea.
Do Joong ParkCancer Research Institute, Seoul National University, Seoul, Korea. djparkmd@snu.ac.kr.
Hyuk-Joon LeeCancer Research Institute, Seoul National University, Seoul, Korea.
Han-Kwang YangCancer Research Institute, Seoul National University, Seoul, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGastric cancer is a major global health issue, especially in advanced stages with metastasis. However, anti-angiogenic treatments such as ramucirumab target vascular endothelial growth factor, yet the exact mechanisms behind hematogenous metastasis remain unclear. This study analyzed RNA sequencing data from TCGA to identify angiogenesis-related genes in metastatic gastric cancer.

methodsPatients were categorized into four metastasis types (non-metastasis, hematogenous, locoregional, and lymphatic) based on clinical data. cBioPortal was used to identify frequently mutated genes across five metastatic cancer studies. RNA sequencing and clinical data were obtained from the TCGA-STAD project. RNA expression levels were compared across metastasis groups using independent-samples t-tests, followed by false discovery rate adjustment for multiple comparisons.

resultsRNA expression analysis was performed using a 132-gene analytical panel in the TCGA-STAD cohort. Among the 95-gene angiogenesis/metastasis-related genes represented in this panel, RAF1, ARID1A, ERBB3, FGFR3, BAP1, TSC2, and KDR showed nominal expression differences in comparisons involving the hematogenous metastasis group. None of these differences remained statistically significant after false discovery rate correction.

conclusionIn this exploratory analysis, several candidate genes with prior literature support showed nominal expression differences in comparisons involving hematogenous metastasis in gastric cancer. These findings are hypothesis-generating and require validation in independent cohorts and functional studies.

Indexed as

Gene expression profilingNeoplasm metastasisStomach neoplasms

Identifiers

PMID42687516
PMCPMC13555262

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