Evidence map›Paper›PMID 42687513›Full record

ArticlePlant biotechnology journal2026

HvPHO1 Controls a Glucose 1-Phosphate-SnRK1 Signalling Module That Coordinates Starch Accumulation in Barley Endosperm.

Yulong Li, Yujia Chen, Jing Liu, Ping Yang, Guangqi Gao, Carlos Guzmán, Qiang Xu, Yazhou Zhang, Yanlin Liu, Pengfei Qi and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yulong LiState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, China.ORCID https://orcid.org/0000-0003-4846-2290
Yujia ChenState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, China.
Jing LiuState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, China.
Ping YangInstitute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-6977-8449
Guangqi GaoInstitute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, China.ORCID https://orcid.org/0000-0001-6990-9499
Carlos GuzmánDepartamento de Genética, Escuela Técnica Superior de Ingeniería Agronómica y de Montes, Edificio Gregor Mendel, Campus de Rabanales, Universidad de Córdoba, Cordoba, Spain.ORCID https://orcid.org/0000-0002-1797-9273
Qiang XuState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, China.ORCID https://orcid.org/0000-0002-8433-8687
Yazhou ZhangState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, China.ORCID https://orcid.org/0000-0002-7372-6596
Yanlin LiuState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, China.
Pengfei QiState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, China.ORCID https://orcid.org/0000-0002-7772-9591
Mei DengState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, China.
Shoufen DaiState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, China.
Jian MaState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, China.ORCID https://orcid.org/0000-0001-6265-7911
Guoyue ChenState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, China.ORCID https://orcid.org/0000-0001-7928-9334
Jirui WangState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, China.
Youliang ZhengState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, China.
Yuming WeiState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, China.ORCID https://orcid.org/0000-0003-1077-1362
Qiantao JiangState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Triticeae Research Institute, Sichuan Agricultural University, Chengdu, China.ORCID https://orcid.org/0000-0003-3192-3732

Funding

Open Foundation of Key Laboratory of Wuliangye-flavor Liquor Solid-state Fermentation 2023JJ011Sichuan Province Science and Technology 2024YFNH0023Sichuan Province Science and Technology 2025YFHZ0113
6 · The paper itself

Abstract

Developing barley grains must balance the use of imported sucrose between soluble sugars and storage starch, but how this balance is controlled remains unclear. Here we show that loss of the plastidial α-glucan phosphorylase HvPHO1 causes starch and soluble sugars to accumulate concurrently in barley grains. Developing pho1 grains showed sustained increases in glucose 1-phosphate (G1P) and adenosine diphosphate glucose (ADP-glucose), and exogenous G1P also promoted starch accumulation, supporting a stimulatory effect of elevated G1P on starch synthesis. G1P directly bound sucrose non-fermenting 1-related protein kinase 1 (HvSnRK1), suppressing its kinase activity and its phosphorylation of sucrose synthase 2 (HvSUSY2); the metabolic phenotypes of snrk1 and susy2 mutants supported a role for this phosphorylation module in sucrose utilization and soluble-sugar homeostasis. HvPHO1 also interacted with the starch-granule initiation factor starch synthase 4 (HvSS4). Loss of HvPHO1 increased the abundance of B-type starch granules and shifted their size distribution, indicating a parallel role in storage-starch organization. pho1 lines showed greater grain dry weight and test weight. Thus, loss of HvPHO1 initiates G1P-mediated metabolic feedback that reconfigures the balance between sucrose utilization and starch accumulation and is associated with enhanced grain carbon deposition and grain weight. These findings reveal G1P-dependent feedback linking starch-precursor status to SnRK1-mediated carbon allocation in barley endosperm.

Identifiers

PMID42687513
PMCPMC13539164

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.